Our future is going to the next level. Once in a while, we go through some news related to the latest discoveries in science and technology. For the first time in human history, researchers from China have used the DNA from two mouse mothers to create a new mouse baby. This discovery completely overhauled natural reproduction system and pushing the boundaries of reproductive science. This is can be easily found out by the DNA test kit.
Mice with two male partners were also born, but only survived a couple of days. This is the best example that shows that the biological barriers to same-sex reproduction can be overcome. Although scientist previously managed to produce baby mice with same-sex partners, those offspring had serious abnormalities and died later.
Why This Experiment Was Carried Out?
Since the decades of 80s, scientists are trying to find the question of why mammals can only undergo sexual reproduction and why in mammals, equal genetic contributions from both a mother and a father are necessary. They have made several conclusions in the past by combining reproduction and regeneration, so they tried to find out where more normal mice with two female partners, or even with two male partners, could be produced.
In the animal kingdom, some species of sharks and Komodo dragons, no genetic contribution from a father is required. Some animals like certain species of birds, fish, and lizards, can reproduce using only one sex.
In the initial years, it was suggested that it is because of a biological phenomenon called “imprinting”. Let us try to understand the imprinting here. When eggs and sperm meet, the DNA from each parent meet and immediately butt heads. In most of the cases, Mom’s DNA create smaller babies to ease the birthing process, on the other hand, dad’s DNA create big and strong babies to make them survive longer. Without the perfect pattern of male and female imprinting, a healthy and viable embryo cannot be produced.
So How The Chinese Biologists Overcome The Genetic Imprinting?
To make mice babies from same-sex partners, biologist deleted some of the genetic imprinted in embryonic stem cells. These cells have just one set of chromosomes like egg and sperm cells do. So the biologist removed the three imprinted regions from the DNA of mother ESC and injected them into the eggs of a female partner to create offspring from two female mice. One main advantage of using ESC is that even before the defective genes are knocked out, they contain less of the imprinting programming that eventually causes maternal or paternal-specific genes to be expressed. The final result of this experiment was about 14% offspring survived, grew to adulthood and were fertile.
On the different side, biologist also tried to create mice baby from two male mouse partners. They deleted the seven imprinted regions to do so as they did in two female partners. But unfortunately, only 2.5% of the offspring survived and most did not survive more than a few days. Even though the result is quite promising because the scientists were not expecting such breakthrough results.
This research shows the future of reproduction system in the future and what is possible for the humans in the upcoming future.
Same-sex parents newborns mice babies via gene editing leading to speculations that the same could be achieved with humans DNA. Even though the experiment on mice is successful, scientists are in doubt that this technique could ever be applied to humans. These is lot to search and find about the future possibility of humans reproduction system. Cause there are lots of gay parents who are willing to have the own child rather then gay adoption.
Most of the embryos that they developed were still abnormal and could not survive for a long time. The average success rate is only 14% with embryos from the two mothers and 2.5% rate with the two fathers. According to some scientists, creating is possible but when you reproduce, you really want to know every factor possible to have a good outcome. There is no method through which we can determine how normal these mice are, such as how susceptible they might be to diseases. Chances are still very low to apply these techniques on humans for clinical purposes and produce good results and it might be too risky to take it that far.